labdane-type diterpene and two flavones from salvia sharifii rech. f. and esfan. and their biological activities

نویسندگان

mohammad hossein farjam department of chemistry, firoozabad branch, islamic azad university, firoozabad, iran.

abdolhossein rustaiyan department of chemistry, science and research branch, islamic azad university, tehran, iran.

elham ezzatzadeh department of chemistry, ardabil branch, islamic azad university, ardabil, iran.

amir reza jassbi medicinal and natural products chemistry research canter, shiraz university of medicinal sciences, shiraz, iran.

چکیده

two flavones, ladanein and 6-hydroxy-5,7,4′-trimethoxyflavone and one labdane-typediterpene, ent-13-epi-manoyloxide, were isolated from an ethyl acetate-methanol extract ofthe aerial parts of salvia sharifii. the compounds were purified using several chromatographicmethods. structural elucidation of the compounds was performed using their 1h and 13c-nmrdata, ei mass and uv spectral data. the compounds have been subjected to antimicrobial,antioxidant and cytotoxic activity. the diterpene showed higher cytotoxic activity than theflavones while the later compounds were better antioxidants compared with the isolatedditerpene.

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منابع مشابه

Labdane-Type Diterpene and Two Flavones from Salvia Sharifii Rech. f. and Esfan. and their Biological Activities

Two flavones, ladanein and 6-hydroxy-5,7,4′-trimethoxyflavone and one labdane-typediterpene, ent-13-epi-manoyloxide, were isolated from an ethyl acetate-methanol extract ofthe aerial parts of Salvia sharifii. The compounds were purified using several chromatographicmethods. Structural elucidation of the compounds was performed using their 1H and 13C-NMRdata, EI mass and UV spectral data. The co...

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Labdane-Type Diterpene and Two Flavones from Salvia Sharifii Rech. f. and Esfan. and their Biological Activities

Two flavones, ladanein and 6-hydroxy-5,7,4′-trimethoxyflavone and one labdane-typediterpene, ent-13-epi-manoyloxide, were isolated from an ethyl acetate-methanol extract ofthe aerial parts of Salvia sharifii. The compounds were purified using several chromatographicmethods. Structural elucidation of the compounds was performed using their 1H and 13C-NMRdata, EI mass and UV spectral data. The co...

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Labdane-Type Diterpene and Two Flavones from Salvia Sharifii Rech. f. and Esfan. and their Biological Activities

Two flavones, ladanein and 6-hydroxy-5,7,4'-trimethoxyflavone and one labdane-type diterpene, ent-13-epi-manoyloxide, were isolated from an ethyl acetate-methanol extract of the aerial parts of Salvia sharifii. The compounds were purified using several chromatographic methods. Structural elucidation of the compounds was performed using their (1)H and (13)C-NMR data, EI mass and UV spectral data...

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عنوان ژورنال:
iranian journal of pharmaceutical research

جلد ۱۲، شماره ۲، صفحات ۳۹۵-۳۹۹

کلمات کلیدی
[ ' t l a d a n e i n ' , 6 , ' h y d r o x y ' , 5 , 7 , ' 4 ' , ' t r i m e t h o x y f l a v o n e ' , ' e n t ' , 1 3 , ' e p i ' , ' m a n o y l o x i d e ' , ' a n t i o x i d a n t ' , ' a n t i m i c r o b i a l ' , ' c y t o t o x i c ' ]

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